Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice
نویسندگان
چکیده
منابع مشابه
The role of notch signaling in the development of intrahepatic bile ducts.
BACKGROUND & AIMS Mutations in Jagged1 , a Notch ligand, cause Alagille syndrome (AGS), a disorder characterized by a paucity of intrahepatic bile ducts (IHBD). The mechanism underlying the contribution of the Notch signaling pathway to IHBD formation, however, remains unknown. Here we investigated the role of Notch signaling in IHBD development. METHODS The expression patterns of Jagged1, No...
متن کاملIntrahepatic Transposition of Bile Ducts
Objective. To describe the intrahepatic bile duct transposition (anatomical variation occurring in intrahepatic ducts) and to determine the frequency of this variation. Material and Methods. The researches were performed randomly on 100 livers of adults, both sexes. Main research methods were anatomical macrodissection. As a criterion for determination of variations in some parts of bile tree, ...
متن کاملCongenital absence of the intrahepatic bile ducts.
Routine histological examination of the liver during the acute stages of neonatal obstructive jaundice, whether of biopsy or of autopsy specimens, reveals a variety of different pathological conditions. Congenital absence of the intrahepatic bile ducts appears to be a rare cause of obstructive jaundice in the newborn. The purpose of this paper is to draw attention to the condition by reporting ...
متن کاملNotch Signaling Regulates Bile Duct Morphogenesis in Mice
BACKGROUND Alagille syndrome is a developmental disorder caused predominantly by mutations in the Jagged1 (JAG1) gene, which encodes a ligand for Notch family receptors. A characteristic feature of Alagille syndrome is intrahepatic bile duct paucity. We described previously that mice doubly heterozygous for Jag1 and Notch2 mutations are an excellent model for Alagille syndrome. However, our pre...
متن کاملCongenital dilatation of the intrahepatic bile ducts with cholangiocarcinoma.
Intrahepatic cholangiocarcinomas were found at necropsy in two previously reported cases of congenital dilatation of the intrahepatic bile ducts. The nature of the developmental abnormality is discussed and compared with other forms of biliary dilatation. Slow-flowing bile for many years probably leads to cholangiocarcinoma.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hepatology
سال: 2009
ISSN: 0270-9139
DOI: 10.1002/hep.23431